Genomic Technologies for Mapping Pathways and Understanding Diseases
Imagine a future where people routinely read their own genomes to explore their individuality and their health. It may sound like science fiction, but scientists today are already able to read the basic DNA blueprint for any species we care to study. The challenge is that the genome sequence is like an encyclopedia written in an alien language, and our ability to record DNA sequences has greatly outpaced our capacity to understand them.
Building on a decade of outstanding innovation in experimental and computational genomics at Harvard University, Frederick Roth, Canada Excellence Research Chair in Integrative Biology, is helping us better understand what genes do and how they impact our health.
Working with his team at the University of Toronto and Mount Sinai Hospital, Roth is exploring new ways to experimentally determine which variants in individual genome sequences are likely to cause disease. They are also exploiting next-generation sequencing methods to map networks of protein interactions, and determine which interactions change under different growth or disease conditions.
Roth’s work will add to the leading-edge systems biology research team already in place at the Lunenfeld-Tanenbaum Research Institute and the University of Toronto. His team includes experimental technologists and computational experts, and operates by fostering collaboration between experts in technology and those in biomedical research.
Roth’s research will help Canada to remain at the forefront of biomedical research, develop highly qualified personnel in this growing field, and contribute innovative products and intellectual property to Canada’s economy.